The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks.

ABSTRACT:

Objective

To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios.

Design

Prospective cohort study documenting the timing of transfusions during active resuscitation and patient outcomes. Data were analyzed using time-dependent proportional hazards models.

Setting

Ten US level I trauma centers.

Patients

Adult trauma patients surviving for 30 minutes after admission who received a transfusion of at least 1 unit of RBCs within 6 hours of admission (n = 1245, the original study group) and at least 3 total units (of RBCs, plasma, or platelets) within 24 hours (n = 905, the analysis group).

Main outcome measure

In-hospital mortality.

Results

Plasma:RBC and p

SUBMITTER: Holcomb JB 

PROVIDER: S-EPMC3740072 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature