Solution phase synthesis of a diverse library of highly substituted isoxazoles.

ABSTRACT: The iodocyclization of O-methyloximes of 2-alkyn-1-ones affords 4-iodoisoxazoles, which undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles. The palladium-catalyzed processes have been adapted to parallel synthesis utilizing commercially available boronic acid, acetylene, styrene, and amine sublibraries. Accordingly, a diverse 51-member library of 3,4,5-trisubstituted isoxazoles has been generated.

SUBMITTER: Waldo JP 

PROVIDER: S-EPMC3750120 | biostudies-literature | 2008 Sep-Oct

REPOSITORIES: biostudies-literature