Spir2; a novel QTL on chromosome 4 contributes to susceptibility to pneumococcal infection in mice.

ABSTRACT:

Background

Streptococcus pneumoniae causes over one million deaths worldwide annually, despite recent developments in vaccine and antibiotic therapy. Host susceptibility to pneumococcal infection and disease is controlled by a combination of genetic and environmental influences, but current knowledge remains limited.

Results

In order to identify novel host genetic variants as predictive risk factors or as potential targets for prophylaxis, we have looked for quantitative trait loci in a mouse model of invasive pneumococcal disease. We describe a novel locus, called Streptococcus pneumoniae infection resistance 2 (Spir2) on Chr4, which influences time to morbidity and the development of bacteraemia post-infection.

Conclusions

The two quantitative trait loci we have ide

SUBMITTER: Wisby L 

PROVIDER: S-EPMC3751763 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature