Transcription of Tnfaip3 is regulated by NF-κB and p38 via C/EBPβ in activated macrophages.

ABSTRACT: Macrophages play a pivotal role in the immune system through recognition and elimination of microbial pathogens. Toll-like receptors (TLRs) on macrophages interact with microbial substances and initiate signal transduction through intracellular adapters. TLR4, which recognizes the lipopolysaccharides (LPS) on Gram-positive and Gram-negative bacteria, triggers downstream signaling mediators and eventually activates IκB kinase (IKK) complex and mitogen-activated protein kinases (MAPKs) such as p38. Previous reports revealed that, in addition to NF-κB, a core transcription factor of the innate immune response, the induction of some LPS-induced genes in macrophages required another transcription factor whose activity depends on p38. However, these additional transcription factors remain to be

SUBMITTER: Lai TY 

PROVIDER: S-EPMC3759409 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature