Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys.

ABSTRACT:

Objective

Concerns about increased breast cancer risk with estrogen and progestin therapy have led to an increased interest in progestin alternatives. The main objective of this study was to determine if bazedoxifene acetate (BZA), a new selective estrogen receptor modulator, will antagonize the proliferative and transcriptional effects of conjugated equine estrogens (CEE) in the breast.

Methods

As part of a 20-month preclinical trial, 95 ovariectomized cynomolgus macaques (Macaca fascicularis) were randomized to receive no treatment or treatment with BZA (20 mg/d), CEE (0.45 mg/d), or BZA and CEE in combination (women's daily equivalent doses). The data presented here include breast effects after 6 months of treatment. Endpoints included histomorphometry, histopathological

SUBMITTER: Ethun KF 

PROVIDER: S-EPMC3762946 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature