Nuclear factor-κB signaling contributes to mechanical ventilation-induced diaphragm weakness*.

ABSTRACT:

Objectives

Although mechanical ventilation is a life-saving measure for patients in respiratory failure, prolonged mechanical ventilation results in diaphragmatic weakness attributable to fiber atrophy and contractile dysfunction. Therefore, identifying the signaling pathways responsible for mechanical ventilation-induced diaphragmatic weakness is important. In this context, it is established that oxidative stress is required for mechanical ventilation-induced diaphragmatic weakness to occur. Numerous redox-sensitive signaling pathways exist in muscle including the transcription factor nuclear factor-κB. Although it has been suggested that nuclear factor-κB contributes to proteolytic signaling in inactivity-induced atrophy in locomotor muscles, the role that nuclear factor-κB plays

SUBMITTER: Smuder AJ 

PROVIDER: S-EPMC3786346 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature