The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa?

ABSTRACT: We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms.

SUBMITTER: Bazan JF 

PROVIDER: S-EPMC3794667 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature