Members of the EpCAM signalling pathway are expressed in gastric cancer tissue and are correlated with patient prognosis.

ABSTRACT:

Background

We investigated the expression of members of the epithelial cell adhesion molecule (EpCAM) signalling pathway in gastric cancer (GC) testing the following hypotheses: are these molecules expressed in GC and are they putatively involved in GC biology.

Methods

The study cohort consisted of 482 patients. The following members of the EpCAM signalling pathway were analysed by immunohistochemistry and were correlated with various clinico-pathological patient characteristics: extracellular domain of EpCAM (EpEX), intracellular domain of EpCAM (EpICD), E-cadherin, β-catenin, presenilin-2 (PSEN2), and ADAM17.

Results

All members of the EpCAM signalling pathway were differentially expressed in GC. The expression correlated significantly with tumour type (EpEX, EpICD,

SUBMITTER: Warneke VS 

PROVIDER: S-EPMC3798952 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature