Ontology highlight
ABSTRACT:
SUBMITTER: Maraver A
PROVIDER: S-EPMC3813920 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Cancer cell 20120801 2
Here, we have investigated the role of the Notch pathway in the generation and maintenance of Kras(G12V)-driven non-small cell lung carcinomas (NSCLCs). We demonstrate by genetic means that γ-secretase and RBPJ are essential for the formation of NSCLCs. Of importance, pharmacologic treatment of mice carrying autochthonous NSCLCs with a γ-secretase inhibitor (GSI) blocks cancer growth. Treated carcinomas present reduced HES1 levels and reduced phosphorylated ERK without changes in phosphorylated ...[more]