Novel soy germ pasta enriched in isoflavones ameliorates gastroparesis in type 2 diabetes: a pilot study.

ABSTRACT:

Objective

To determine the effect of soy germ pasta enriched in biologically active isoflavone aglycons on gastric emptying in type 2 diabetic patients with gastroparesis.

Research design and methods

This randomized double-blind, placebo-controlled study compared soy germ pasta with conventional pasta for effects on gastric emptying. Patients (n = 10) with delayed gastric emptying consumed one serving per day of each pasta for 8 weeks, with a 4-week washout. Gastric emptying time (t1/2) was measured using the [(13)C]octanoic acid breath test at baseline and after each period, and blood glucose and insulin concentrations were determined after oral glucose load.

Results

Soy germ pasta significantly accelerated the t1/2 in these patients (161.2 ± 17.5 min at baseline vs.

SUBMITTER: Setchell KD 

PROVIDER: S-EPMC3816848 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature