Role of p38MAPK and oxidative stress in copper-induced senescence.
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ABSTRACT:
SUBMITTER: Boilan E
PROVIDER: S-EPMC3824981 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
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Role of p38MAPK and oxidative stress in copper-induced senescence.
Boilan Emmanuelle E Winant Virginie V Dumortier Elise E Piret Jean-Pascal JP Bonfitto François F Osiewacz Heinz D HD Debacq-Chainiaux Florence F Toussaint Olivier O
Age (Dordrecht, Netherlands) 20130412 6
In the present work, we indicate that copper is involved in the senescence of human diploid fibroblasts and we describe mechanisms to explain it. Using different techniques, we show for the first time an accumulation of copper in cells during replicative senescence. This accumulation seems to be co-localized with lipofuscin. Second, we observed that an incubation of cells with copper sulfate induced oxidative stress, antioxidant response and premature senescence. Antioxidant molecules reduced th ...[more]
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