A synthesis of the chlorosulfolipid mytilipin A via a longest linear sequence of seven steps.

ABSTRACT: Magnificent seven: The chlorosulfolipid mytilipin A was synthesized in racemic form in seven steps and in enantioenriched form in eight steps. Key transformations include a highly diastereoselective bromoallylation of a sensitive α,β-dichloroaldehyde, a kinetic resolution of a vinyl epoxide, a convergent and highly Z-selective alkene cross-metathesis, and a chemoselective and diastereoselective dichlorination of a complex diene.

SUBMITTER: Chung WJ 

PROVIDER: S-EPMC3835569 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature