Ontology based molecular signatures for immune cell types via gene expression analysis.

ABSTRACT:

Background

New technologies are focusing on characterizing cell types to better understand their heterogeneity. With large volumes of cellular data being generated, innovative methods are needed to structure the resulting data analyses. Here, we describe an 'Ontologically BAsed Molecular Signature' (OBAMS) method that identifies novel cellular biomarkers and infers biological functions as characteristics of particular cell types. This method finds molecular signatures for immune cell types based on mapping biological samples to the Cell Ontology (CL) and navigating the space of all possible pairwise comparisons between cell types to find genes whose expression is core to a particular cell type's identity.

Results

We illustrate this ontological approach by evaluating expressi

SUBMITTER: Meehan TF 

PROVIDER: S-EPMC3844401 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature