Clostridium thermocellum transcriptomic profiles after exposure to furfural or heat stress.

ABSTRACT:

Background

The thermophilic anaerobe Clostridium thermocellum is a candidate consolidated bioprocessing (CBP) biocatalyst for cellulosic ethanol production. It is capable of both cellulose solubilization and its fermentation to produce lignocellulosic ethanol. Intolerance to stresses routinely encountered during industrial fermentations may hinder the commercial development of this organism. A previous C. thermocellum ethanol stress study showed that the largest transcriptomic response was in genes and proteins related to nitrogen uptake and metabolism.

Results

In this study, C. thermocellum was grown to mid-exponential phase and treated with furfural or heat to a final concentration of 3 g.L-1 or 68°C respectively to investigate general and specific physiological and regula

SUBMITTER: Wilson CM 

PROVIDER: S-EPMC3848806 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature