Screening of key genes in gastric cancer with DNA microarray analysis.

ABSTRACT:

Background

The aim of this study was to identify key genes and novel potential therapeutic targets related to gastric cancer (GC) by comparing cancer tissue samples and healthy control samples using DNA microarray analysis.

Methods

Microarray data set GSE19804 was downloaded from Gene Expression Omnibus. Preprocessing and differential analysis were conducted with of R statistical software packages, and a number of differentially expressed genes (DEGs) were obtained. Cluster analysis was also done with gene expression values. Functional enrichment analysis was performed for all the DEGs with DAVID tools. The significantly up- and downregulated genes were selected out and their interactors were retrieved with STRING and HitPredict, followed by construction of networks. For all

SUBMITTER: Jin Y 

PROVIDER: S-EPMC3852022 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature