Ontology highlight
ABSTRACT:
SUBMITTER: Yamamizu K
PROVIDER: S-EPMC3871400 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Yamamizu Kohei K Piao Yulan Y Sharov Alexei A AA Zsiros Veronika V Yu Hong H Nakazawa Kazu K Schlessinger David D Ko Minoru S H MS
Stem cell reports 20131127 6
A network of transcription factors (TFs) determines cell identity, but identity can be altered by overexpressing a combination of TFs. However, choosing and verifying combinations of TFs for specific cell differentiation have been daunting due to the large number of possible combinations of ∼2,000 TFs. Here, we report the identification of individual TFs for lineage-specific cell differentiation based on the correlation matrix of global gene expression profiles. The overexpression of identified ...[more]