Dataset Information

RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case-control study.

ABSTRACT:

Objectives

Our study aimed to investigate the association of CYP2E1 C-1019T RsaI and T7678A DraI polymorphisms and factors such as age, gender and ethnicity to the risk of gastrointestinal cancer (GIC) in Malaysians.

Design

Case-control study.

Setting

Malaysia.

Participants

520 consented healthy blood donors with no previous GIC record and 175 patients with GIC.

Measurements

C-1019T RsaI and T7678A DraI genotyping of CYP2E1 gene; direct sequencing.

Results

This study reveals that the variant c2 allele and carrier with at least one c2 allele of C-1019T single nucleotide polymorphism (SNP) significantly increased the risk of GIC but no significant association was found between T7678A SNP and combined analysis of C-1019T and T7678A SNPs to risk of GIC. The Malaysian Chinese had greater risk of GIC compared with the Malays, Indians and KadazanDusun. An increased risk of GIC was observed in individuals aged >40 years and women had a 2.22-fold and 1.58-fold increased risk of stomach and colorectal cancers, respectively, when compared with men.

Limitations

The future research should be conducted with a larger sample population and including the gene-gene and gene-environmental interactions.

Conclusions

Our study suggests that the rare c2 allele and carrier with at least one c2 allele of CYP2E1 RsaI polymorphism significantly elevated the risk of GIC and may be used as a genetic biomarker for early screening of GIC in Malaysians. The risk age-group has been shifted to a younger age at 40s and women showed a significant greater risk of stomach and colorectal cancers than men.

SUBMITTER: Chong ET

PROVIDER: S-EPMC3902529 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case-control study.

Chong Eric Tzyy Jiann ET Lee Chong Cin CC Chua Kek Heng KH Chuah Jitt Aun JA Lee Ping-Chin PC

BMJ open 20140106 1

<h4>Objectives</h4>Our study aimed to investigate the association of CYP2E1 C-1019T RsaI and T7678A DraI polymorphisms and factors such as age, gender and ethnicity to the risk of gastrointestinal cancer (GIC) in Malaysians.<h4>Design</h4>Case-control study.<h4>Setting</h4>Malaysia.<h4>Participants</h4>520 consented healthy blood donors with no previous GIC record and 175 patients with GIC.<h4>Measurements</h4>C-1019T RsaI and T7678A DraI genotyping of CYP2E1 gene; direct sequencing.<h4>Results< ...[more]

PMID: 24394801

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Dataset Information

RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case-control study.

Objectives

Design

Setting

Participants

Measurements

Results

Limitations

Conclusions

Publications

RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case-control study.

Similar Datasets

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