RsaI but not DraI polymorphism in CYP2E1 gene increases the risk of gastrointestinal cancer in Malaysians: a case-control study.

ABSTRACT:

Objectives

Our study aimed to investigate the association of CYP2E1 C-1019T RsaI and T7678A DraI polymorphisms and factors such as age, gender and ethnicity to the risk of gastrointestinal cancer (GIC) in Malaysians.

Design

Case-control study.

Setting

Malaysia.

Participants

520 consented healthy blood donors with no previous GIC record and 175 patients with GIC.

Measurements

C-1019T RsaI and T7678A DraI genotyping of CYP2E1 gene; direct sequencing.

Results

This study reveals that the variant c2 allele and carrier with at least one c2 allele of C-1019T single nucleotide polymorphism (SNP) significantly increased the risk of GIC but no significant association was found between T7678A SNP and combined analysis of C-1019T and T7678A SNPs to risk of GI

SUBMITTER: Chong ET 

PROVIDER: S-EPMC3902529 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature