RNF14 is a regulator of mitochondrial and immune function in muscle.

ABSTRACT:

Background

Muscle development and remodelling, mitochondrial physiology and inflammation are thought to be inter-related and to have implications for metabolism in both health and disease. However, our understanding of their molecular control is incomplete.

Results

In this study we have confirmed that the ring finger 14 protein (RNF14), a poorly understood transcriptional regulator, influences the expression of both mitochondrial and immune-related genes. The prediction was based on a combination of network connectivity and differential connectivity in cattle (a non-model organism) and mice data sets, with a focus on skeletal muscle. They assigned similar probability to mammalian RNF14 playing a regulatory role in mitochondrial and immune gene expression. To try and resolve

SUBMITTER: Ingham AB 

PROVIDER: S-EPMC3906743 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature