Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the centromedian-parafascicular (CM-Pf) thalamic nuclei has been considered an option for treating Tourette syndrome. Using a large animal DBS model, this study was designed to explore the network effects of CM-Pf DBS.

Methods

The combination of DBS and functional magnetic resonance imaging is a powerful means of tracing brain circuitry and testing the modulatory effects of electrical stimulation on a neuronal network in vivo. With a within-subjects design, we tested the proportional effects of CM and Pf DBS by manipulating current spread and varying stimulation contacts in healthy pigs (n = 5).

Results

Our results suggests that CM-Pf DBS has an inhibitory modulating effect in areas that have been suggested as contributing to

SUBMITTER: Kim JP 

PROVIDER: S-EPMC3910443 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature