Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort.

ABSTRACT:

Background

Leukemia incidence has increased in recent decades among European children, suggesting that early-life environmental exposures play an important role in disease development.

Objectives

We investigated the hypothesis that childhood susceptibility may increase as a result of in utero exposure to carcinogens and hormonally acting factors. Using cord blood samples from the NewGeneris cohort, we examined associations between a range of biomarkers of carcinogen exposure and hormonally acting factors with micronuclei (MN) frequency as a proxy measure of cancer risk. Associations with gene expression and genotype were also explored.

Methods

DNA and protein adducts, gene expression profiles, circulating hormonally acting factors, and GWAS (genome-wide association st

SUBMITTER: Merlo DF 

PROVIDER: S-EPMC3914866 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature