The complex pathogenesis of bacteremia: from antimicrobial clearance mechanisms to the genetic background of the host.
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ABSTRACT:
SUBMITTER: Christaki E
PROVIDER: S-EPMC3916384 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
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The complex pathogenesis of bacteremia: from antimicrobial clearance mechanisms to the genetic background of the host.
Christaki Eirini E Giamarellos-Bourboulis Evangelos J EJ
Virulence 20130925 1
Bacteremia develops when bacteria manage to escape the host immune mechanisms or when the otherwise well-orchestrated immune response fails to control bacterial spread due to inherent or acquired immune defects that are associated with susceptibility to infection. The pathogenesis of bacteremia has some characteristic features that are influenced by the genetic signature of the host. In this review, the host defense mechanisms that help prevent bacteremia will be described and the populations wh ...[more]
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