Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group.

ABSTRACT:

Purpose

The strong dose-dependent association between anthracyclines and cardiomyopathy is further exacerbated by the co-occurrence of cardiovascular risk factors (diabetes and hypertension). The high morbidity associated with cardiomyopathy necessitates an understanding of the underlying pathogenesis so that targeted interventions can be developed.

Patients and methods

By using a two-stage design, we investigated host susceptibility to anthracycline-related cardiomyopathy by using the ITMAT/Broad CARe cardiovascular single nucleotide polymorphism (SNP) array to profile common SNPs in 2,100 genes considered relevant to de novo cardiovascular disease.

Results

By using a matched case-control design (93 cases, 194 controls), we identified a common SNP, rs2232228, in the

SUBMITTER: Wang X 

PROVIDER: S-EPMC3927733 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature