Ontology highlight
ABSTRACT:
SUBMITTER: Kazane SA
PROVIDER: S-EPMC3951380 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20121221 1
With the recent clinical success of bispecific antibodies, a strategy to rapidly synthesize and evaluate bispecific or higher order multispecific molecules could facilitate the discovery of new therapeutic agents. Here, we show that unnatural amino acids (UAAs) with orthogonal chemical reactivity can be used to generate site-specific antibody-oligonucleotide conjugates. These constructs can then be self-assembled into multimeric complexes with defined composition, valency, and geometry. With thi ...[more]