Small-animal PET of steroid hormone receptors predicts tumor response to endocrine therapy using a preclinical model of breast cancer.

ABSTRACT:

Unlabelled

Estrogen receptor-α (ERα) and progesterone receptor (PR) are expressed in most human breast cancers and are important predictive factors for directing therapy. Because of de novo and acquired resistance to endocrine therapy, there remains a need to identify which ERα-positive (ERα(+))/PR-positive (PR(+)) tumors are most likely to respond. The purpose of this study was to use estrogen- and progestin-based radiopharmaceuticals to image ERα and PR in mouse mammary tumors at baseline and after hormonal therapy and to determine whether changes in these imaging biomarkers can serve as an early predictive indicator of therapeutic response.

Methods

Mammary adenocarcinomas that spontaneously develop in aged female mice deficient in signal transducer and activator of transc

SUBMITTER: Fowler AM 

PROVIDER: S-EPMC3956595 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature