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Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.

ABSTRACT: The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acetylation.

SUBMITTER: Klein BJ 

PROVIDER: S-EPMC3962528 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.

Klein Brianna J BJ   Lalonde Marie-Eve ME   Côté Jacques J   Yang Xiang-Jiao XJ   Kutateladze Tatiana G TG  

Epigenetics 20131029 2

The MOZ/MORF complexes represent an example of a chromatin-binding assembly whose recruitment to specific genomic regions and activity can be fine-tuned by posttranslational modifications of histones. Here we detail the structures and biological functions of epigenetic readers present in the four core subunits of the MOZ/MORF complexes, highlight the imperative role of combinatorial readout by the multiple readers, and discuss new research directions to advance our understanding of histone acety  ...[more]

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