Stem cells for myocardial repair with use of a transarterial catheter.

ABSTRACT:

Background

Using a swine model of postinfarction left ventricle (LV) remodeling, we investigated marrow-derived, multipotent progenitor cell (MPC) transplantation into hearts with acute myocardial infarction (AMI) via a novel transarterial catheter.

Methods and results

The left anterior descending coronary artery was balloon-occluded after percutaneous transluminal angiography to generate AMI (60-minute no-flow ischemia). The transarterial catheter was then placed in the same coronary artery, and either 50x10(6) MPCs (cell group, n=6) or saline (control, n=6) was injected into the border zone (BZ) myocardium. LV function was assessed by magnetic resonance imaging before AMI and at 1 and 4 weeks after AMI, whereas myocardial energy metabolism was assessed by (31)P-magnetic re

SUBMITTER: Wang X 

PROVIDER: S-EPMC3977692 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature