Effects of withdrawal from chronic escalating-dose binge cocaine on conditioned place preference to cocaine and striatal preproenkephalin mRNA in C57BL/6J mice.

ABSTRACT:

Unlabelled

Relapse is a serious problem for the effective treatment of cocaine addiction.

Rationale

Examining cocaine re-exposure-induced behavioral and neurobiological alterations following chronic escalating-dose binge cocaine administration and withdrawal may provide insight into the neurobiological basis of cocaine relapse.

Objectives

Our goal was to determine how exposure to chronic escalating-dose cocaine affects development of subsequent cocaine-induced conditioned place preference (CPP) and changes in endogenous opioid systems.

Methods

Mice were injected with either escalating-dose binge cocaine (15-30 mg/kg/injection × 3/day) or saline for 14-days and conditioned with 15 mg/kg of cocaine or saline (once per day for 10-days), starting either 1 or 14-day

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3979702 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature