Association between two common polymorphisms and risk of hepatocellular carcinoma: evidence from an updated meta-analysis.

ABSTRACT:

Background

Recent studies suggested that two common polymorphisms, miR-146a G>C and miR-196a2 C>T, may be associated with individual susceptibility to hepatocellular carcinoma (HCC). However, the results remain conflicting rather than conclusive. Object. The aim of this study was to assess the association between miR-146a G>C and miR-196a2 C>T polymorphisms and the risk of HCC.

Methods

A meta-analysis of 17 studies (10938 cases and 11967 controls) was performed. Odds ratios and 95% confidence intervals were used to evaluate the strength of the association.

Results

For miR-146a G>C, the variant genotypes were associated with a decreased risk of HCC (CC versus GG: OR = 0.780 and 95% CI 0.700-0.869; GC/CC versus GG: OR = 0.865 and 95% CI 0.787-0.952; CC versus GC/GG: OR

SUBMITTER: Wang Z 

PROVIDER: S-EPMC4016853 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature