Ontology highlight
ABSTRACT:
SUBMITTER: Patane M
PROVIDER: S-EPMC4029392 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Molecular cancer 20131211
The NF-kB family of transcription factors is up-regulated in inflammation and different cancers. Recent data described heterozygous deletions of the NF-kB Inhibitor alpha gene (NFKBIA) in about 20% of glioblastomas (GBM): deletions were mutually exclusive with epidermal growth factor receptor (EGFR) amplification, a frequent event in GBM. We assessed the status of NFKBIA and EGFR in 69 primary GBMs and in corresponding neurospheres (NS). NFKBIA deletion was investigated by the copy number variat ...[more]