Conventional hypoglycaemic agents and the risk of lung cancer in patients with diabetes: a meta-analysis.

ABSTRACT:

Background

Accumulating evidence suggests that hypoglycaemic agents influence lung cancer risk in patients with diabetes. It remains to be fully elucidated whether conventional hypoglycaemic agents (metformin, sulfonylureas, thiazolidinediones [TZDs] or insulin) affect lung cancer incidence in patients with diabetes.

Methods

We performed a meta-analysis using EMBASE, MEDLINE and Web of Science to search randomised controlled trials (RCTs), cohort studies, and case-control studies published up to October 2013 that assessed the effects of metformin, sulfonylurea, TZDs or insulin on lung cancer risk in subjects with diabetes. Fixed and random effects meta-analysis models were used, and the effect size was expressed as a summary odds ratio (OR) with 95% confidence intervals (CI)

SUBMITTER: Wu Y 

PROVIDER: S-EPMC4055722 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature