Bioactive equivalence of combinatorial components identified in screening of an herbal medicine.

ABSTRACT:

Purpose

To identify bioactive equivalent combinatorial components (BECCs) in herbal medicines. The exact composition of effective components in herbal medicines is often elusive due to the lack of adequate screening methodology. Herein, we propose a hypothesis that BECCs accounting for the whole efficacy of original herbal medicines could be discovered from a complex mixture of constituents.

Methods

We developed a bioactive equivalence oriented feedback screening method and applied it to discover the BECCs from an herbal preparation Cardiotonic Pill (CP). The operations include chemical profiling of CP, followed by an iterative loop of determining, collecting and evaluating candidate BECCs.

Results

A combination of 18 compounds was identified as BECCs from CP, which a

SUBMITTER: Liu P 

PROVIDER: S-EPMC4062815 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature