Oxygen-Mediated Enzymatic Polymerization of Thiol-Ene Hydrogels.

ABSTRACT: Materials that solidify in response to an initiation stimulus are currently utilized in several biomedical and surgical applications; however, their clinical adoption would be more widespread with improved physical properties and biocompatibility. One chemistry that is particularly promising is based on the thiol-ene addition reaction, a radical-mediated step-growth polymerization that is resistant to oxygen inhibition and thus is an excellent candidate for materials that polymerize upon exposure to aerobic conditions. Here, thiol-ene-based hydrogels are polymerized by exposing aqueous solutions of multi-functional thiol and allyl ether PEG monomers, in combination with enzymatic radical initiating systems, to air. An initiating system based on glucose oxidase, glucose, and Fe²⁺

SUBMITTER: Zavada SR 

PROVIDER: S-EPMC4074923 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature