Genes associated with prostate cancer are differentially expressed in African American and European American men.

ABSTRACT:

Background

Despite more aggressive screening across all demographics and gradual declines in mortality related to prostate cancer (PCa) in the United States, disparities among populations persist. A substantial proportion of African American men (AAM) have a higher overall incidence, earlier age of onset, increased proportion of clinically advanced disease, and increased bone metastases and mortality from PCa compared to European American men (EAM). Limited early evidence indicates that underlying causes for disparities may be observed in tumor-specific gene expression programs.

Methods

This study used microarray-based methods to measure expression levels for 517 genes that were previously associated with PCa in archived formalin-fixed paraffin embedded (FFPE) specimens; tes

SUBMITTER: Powell IJ 

PROVIDER: S-EPMC4097306 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature