Ontology highlight
ABSTRACT:
SUBMITTER: Xiao Y
PROVIDER: S-EPMC4097670 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Xiao Yang Y Lin Vivian Y VY Ke Shi S Lin Gregory E GE Lin Fang-Tsyr FT Lin Weei-Chin WC
Molecular and cellular biology 20140701 14
14-3-3τ is frequently overexpressed in breast cancer; however, whether it contributes to breast cancer progression remains undetermined. Here, we identify a critical role for 14-3-3τ in promoting breast cancer metastasis, in part through binding to and inhibition of RhoGDIα, a negative regulator of Rho GTPases and a metastasis suppressor. 14-3-3τ binds Ser174-phosphorylated RhoGDIα and blocks its association with Rho GTPases, thereby promoting epidermal growth factor (EGF)-induced RhoA, Rac1, an ...[more]