Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC7001506 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Liu Jiwei J Feng Jingxin J Li Lili L Lin Luyao L Ji Jiafei J Lin Cong C Liu Lingxia L Zhang Na N Duan Dandan D Li Zhongwei Z Huang Baiqu B Zhang Yu Y Lu Jun J
EMBO reports 20191212 2
Histone lysine demethylase 1 (LSD1), the first identified histone demethylase, is overexpressed in multiple tumor types, including breast cancer. However, the mechanisms that cause LSD1 dysregulation in breast cancer remain largely unclear. Here, we report that protein arginine methyltransferase 4 (PRMT4 or CARM1) dimethylates LSD1 at R838, which promotes the binding of the deubiquitinase USP7, resulting in the deubiquitination and stabilization of LSD1. Moreover, CARM1- and USP7-dependent LSD1 ...[more]