Chromatin dynamics: interplay between remodeling enzymes and histone modifications.

ABSTRACT: Chromatin dynamics play an essential role in regulating the accessibility of genomic DNA for a variety of nuclear processes, including gene transcription and DNA repair. The posttranslational modification of the core histones and the action of ATP-dependent chromatin remodeling enzymes represent two primary mechanisms by which chromatin dynamics are controlled and linked to nuclear events. Although there are examples in which a histone modification or a remodeling enzyme may be sufficient to drive a chromatin transition, these mechanisms typically work in concert to integrate regulatory inputs, leading to a coordinated alteration in chromatin structure and function. Indeed, site-specific histone modifications can facilitate the recruitment of chromatin remodeling enzymes to particular geno

SUBMITTER: Swygert SG 

PROVIDER: S-EPMC4099280 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature