Development of a new photochromic ion channel blocker via azologization of fomocaine.
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ABSTRACT:
SUBMITTER: Schoenberger M
PROVIDER: S-EPMC4102962 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Development of a new photochromic ion channel blocker via azologization of fomocaine.
Schoenberger Matthias M Damijonaitis Arunas A Zhang Zinan Z Nagel Daniel D Trauner Dirk D
ACS chemical neuroscience 20140605 7
Photochromic blockers of voltage gated ion channels are powerful tools for the control of neuronal systems with high spatial and temporal precision. We now introduce fotocaine, a new type of photochromic channel blocker based on the long-lasting anesthetic fomocaine. Fotocaine is readily taken up by neurons in brain slices and enables the optical control of action potential firing by switching between 350 and 450 nm light. It also provides an instructive example for "azologization", that is, the ...[more]
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