AAML0523: a report from the Children's Oncology Group on the efficacy of clofarabine in combination with cytarabine in pediatric patients with recurrent acute myeloid leukemia.

ABSTRACT:

Background

The discovery of new, effective non-anthracycline-based reinduction regimens for children with recurrent acute myeloid leukemia (AML) is critical. In this phase 1/2 study, the tolerability and overall response rate of clofarabine in combination with cytarabine was investigated in children with recurrent/refractory AML.

Methods

AAML0523 enrolled 49 children with AML in first recurrence or who were refractory to induction therapy. The study consisted of a dose-finding phase (9 patients) and an efficacy phase (40 patients). Two children received clofarabine at a dose of 40 mg/m(2)/day and 47 children at a dose of 52 mg/m(2)/day.

Results

Toxicities typical for intensive chemotherapy regimens were observed at all doses of clofarabine. The recommended pediatric p

SUBMITTER: Cooper TM 

PROVIDER: S-EPMC4126862 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature