Effects of varenicline and bupropion sustained-release use plus intensive smoking cessation counseling on prolonged abstinence from smoking and on depression, negative affect, and other symptoms of nicotine withdrawal.

ABSTRACT:

Importance

Given the actions of varenicline tartrate and bupropion hydrochloride sustained-release (SR) on neurobiological targets related to affect and reward, it is thought that the modulation of nicotine withdrawal symptoms may contribute to their effectiveness.

Objective

To assess the relative efficacy of varenicline and bupropion SR plus intensive counseling on smoking cessation and emotional functioning.

Design and setting

Placebo-controlled randomized clinical trial at a university medical center.

Participants

In total, 294 community volunteers who wanted to quit smoking.

Interventions

Twelve weeks of varenicline, bupropion SR, or placebo plus intensive smoking cessation counseling (10 sessions, for a total of approximately 240 minutes of counseli

SUBMITTER: Cinciripini PM 

PROVIDER: S-EPMC4128024 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature