Ontology highlight
ABSTRACT:
SUBMITTER: Lee T
PROVIDER: S-EPMC4132785 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Lee Teresa T Di Paola Domenic D Malina Abba A Mills John R JR Kreps Amina A Grosse Frank F Tang Hengli H Zannis-Hadjopoulos Maria M Larsson Ola O Pelletier Jerry J
The Journal of biological chemistry 20140702 33
DHX9 is an ATP-dependent DEXH box helicase with a multitude of cellular functions. Its ability to unwind both DNA and RNA, as well as aberrant, noncanonical polynucleotide structures, has implicated it in transcriptional and translational regulation, DNA replication and repair, and maintenance of genome stability. We report that loss of DHX9 in primary human fibroblasts results in premature senescence, a state of irreversible growth arrest. This is accompanied by morphological defects, elevation ...[more]