Lower expressions of the human bitter taste receptor TAS2R in smokers: reverse transcriptase-polymerase chain reaction analysis.

ABSTRACT:

Background

Despite the fact that smokers have deficit in detecting taste, particularly bitter taste, no study has investigated its biological correlate.

Methods

In this context, we compared the expression of the bitter taste receptor gene, taste 2 receptor (TAS2R) in the tongues of smokers and non-smokers. Tissue samples were collected from the lateral portion of the tongues of 22 smokers and 22 age- and gender-matched healthy volunteers (19 males and three females) with no history of smoking. Reverse transcriptase-polymerase chain reaction was used to examine the expression of TAS2R in the two groups, and the effect of aging on TAS2R expression was also assessed.

Results

TAS2R expression was significantly lower among smokers than non-smokers (t = 6.525, P < .0001, 11

SUBMITTER: Aoki M 

PROVIDER: S-EPMC4142065 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature