Motoric cognitive risk syndrome: multicountry prevalence and dementia risk.

ABSTRACT:

Objectives

Our objective is to report prevalence of motoric cognitive risk syndrome (MCR), a newly described predementia syndrome characterized by slow gait and cognitive complaints, in multiple countries, and its association with dementia risk.

Methods

Pooled MCR prevalence analysis of individual data from 26,802 adults without dementia and disability aged 60 years and older from 22 cohorts from 17 countries. We also examined risk of incident cognitive impairment (Mini-Mental State Examination decline ≥4 points) and dementia associated with MCR in 4,812 individuals without dementia with baseline Mini-Mental State Examination scores ≥25 from 4 prospective cohort studies using Cox models adjusted for potential confounders.

Results

At baseline, 2,808 of the 26,802 parti

SUBMITTER: Verghese J 

PROVIDER: S-EPMC4150127 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature