Comparative genomics of nucleotide metabolism: a tour to the past of the three cellular domains of life.

ABSTRACT:

Background

Nucleotide metabolism is central to all biological systems, due to their essential role in genetic information and energy transfer, which in turn suggests its possible presence in the last common ancestor (LCA) of Bacteria, Archaea and Eukarya. In this context, elucidation of the contribution of the origin and diversification of de novo and salvage pathways of nucleotide metabolism will allow us to understand the links between the enzymatic steps associated with the LCA and the emergence of the first metabolic pathways.

Results

In this work, the taxonomical distribution of the enzymes associated with nucleotide metabolism was evaluated in 1,606 complete genomes. 151 sequence profiles associated with 120 enzymatic reactions were used. The evaluation was based on pr

SUBMITTER: Armenta-Medina D 

PROVIDER: S-EPMC4177761 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature