Ontology highlight
ABSTRACT:
SUBMITTER: Prater MD
PROVIDER: S-EPMC4183554 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Nature cell biology 20140831 10
Contractile myoepithelial cells dominate the basal layer of the mammary epithelium and are considered to be differentiated cells. However, we observe that up to 54% of single basal cells can form colonies when seeded into adherent culture in the presence of agents that disrupt actin-myosin interactions, and on average, 65% of the single-cell-derived basal colonies can repopulate a mammary gland when transplanted in vivo. This indicates that a high proportion of basal myoepithelial cells can give ...[more]