Soluble ST2 in ambulatory patients with heart failure: Association with functional capacity and long-term outcomes.

ABSTRACT:

Background

ST2 is involved in cardioprotective signaling in the myocardium and has been identified as a potentially promising biomarker in heart failure (HF). We evaluated ST2 levels and their association with functional capacity and long-term clinical outcomes in a cohort of ambulatory patients with HF enrolled in the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study-a multicenter, randomized study of exercise training in HF.

Methods and results

HF-ACTION randomized 2331 patients with left ventricular ejection fraction <0.35 and New York Heart Association class II to IV HF to either exercise training or usual care. ST2 was analyzed in a subset of 910 patients with evaluable plasma samples. Correlations and Cox models were used t

SUBMITTER: Felker GM 

PROVIDER: S-EPMC4188425 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature