In vivo P-glycoprotein function before and after epilepsy surgery.

ABSTRACT:

Objectives

To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[(11)C]verapamil (VPM)-PET before and after temporal lobe surgery to assess whether postoperative changes in seizure frequency and antiepileptic drug load are associated with changes in Pgp function.

Methods

Seven patients with drug-resistant temporal lobe epilepsy underwent VPM-PET scans pre- and postsurgery. Patients were followed up for a median of 6 years (range 4-7) after surgery. Pgp immunoreactivity in surgically resected hippocampal specimens was determined with immunohistochemistry.

Results

Optimal surgical outcome, defined as seizure freedom and withdrawal of antiepileptic drugs, was

SUBMITTER: Bauer M 

PROVIDER: S-EPMC4189097 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature