Prenatal exposure to air toxics and risk of Wilms' tumor in 0- to 5-year-old children.

ABSTRACT:

Objective

To study prenatal air toxic exposure and Wilms' tumor in children.

Methods

We identified 337 Wilms' tumor cases among children younger than 6 years (1988 to 2008) from the California Cancer Registry, randomly selected 96,514 controls from California birth rolls in 20:1 ratio matched to all cancer cases, then linked birth addresses to air monitors within 15 miles to assess exposures. Multiple logistic regressions were applied to estimate effects.

Results

Children prenatally exposed to formaldehyde, polycyclic aromatic hydrocarbons, perchloroethylene, or acetaldehyde in the third trimester had an increased odds of Wilms' tumor per interquartile increase in concentration (odds ratio [95% confidence interval]: 1.28 [1.12 to 1.45], 1.10 [0.99 to 1.22], 1.09 [1.00

SUBMITTER: Shrestha A 

PROVIDER: S-EPMC4204106 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature