Total synthesis of (-)-N-methylwelwitindolinone B isothiocyanate via a chlorinative oxabicycle ring-opening strategy.

ABSTRACT: The first total synthesis of N-methylwelwitindolinone B isothiocyanate is reported. The route features several key steps, including a regio- and diastereoselective chlorinative oxabicycle ring-opening reaction to introduce the challenging alkyl chloride motif.

SUBMITTER: Weires NA 

PROVIDER: S-EPMC4206695 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature