Total synthesis of the proposed structure of astakolactin.

ABSTRACT: The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson-Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.

SUBMITTER: Tonoi T 

PROVIDER: S-EPMC4222296 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature