Subdoses of 17DD yellow fever vaccine elicit equivalent virological/immunological kinetics timeline.

ABSTRACT:

Background

The live attenuated 17DD Yellow Fever vaccine is one of the most successful prophylactic interventions for controlling disease expansion ever designed and utilized in larger scale. However, increase on worldwide vaccine demands and manufacturing restrictions urge for more detailed dose sparing studies. The establishment of complementary biomarkers in addition to PRNT and Viremia could support a secure decision-making regarding the use of 17DD YF vaccine subdoses. The present work aimed at comparing the serum chemokine and cytokine kinetics triggered by five subdoses of 17DD YF Vaccine.

Methods

Neutralizing antibody titers, viremia, cytokines and chemokines were tested on blood samples obtained from eligible primary vaccinees.

Results and discussion

The resu

SUBMITTER: Campi-Azevedo AC 

PROVIDER: S-EPMC4223624 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature